Sugi Predict

Sugi Predict / Compounds / SCHEMBL14697013

SCHEMBL14697013

SCHEMBL14697013

COC(=O)c1ccccc1S(=O)(=O)N1CCOCC1

nearest known ligand 0.60

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 2/20 0.56
▸ CA1 P00915 1/20 0.54
▸ CA2 P00918 1/20 0.54
▸ CA5A P35218 1/20 0.54
▸ CA9 Q16790 1/20 0.54
▸ ALDH1A1 P00352 2/20 0.54
▸ LMNA P02545 1/20 0.54
▸ GAA P10253 1/20 0.54
▸ NPC1 O15118 1/20 0.53
▸ POLB P06746 2/20 0.52
▸ CNR1 P21554 3/20 0.51
▸ CNR2 P34972 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15936325 0.88 ALDH1A1 (0.50) HSD17B10ALDH1A1LMNAGAANPC1
SCHEMBL8337431 0.87 CA1 (0.58) HSD17B10CA1CA2CA5ACA9
SCHEMBL1990490 0.82 ALDH1A1 (0.61) ALDH1A1GAAPOLBCNR1
SCHEMBL14477864 0.82 POLB (0.53) HSD17B10CA1CA2CA5ACA9
SCHEMBL1256021 0.81 CNR1 (0.51) ALDH1A1LMNAGAANPC1POLB
SCHEMBL1987895 0.81 CNR1 (0.54) ALDH1A1LMNAGAANPC1POLB
SCHEMBL29467287 0.81 CNR1 (0.51) ALDH1A1LMNAGAANPC1POLB
SCHEMBL14696892 0.81 CA1 (0.55) CA1CA2CA9ALDH1A1LMNA
SCHEMBL7080602 0.80 MAPT (0.65) HSD17B10ALDH1A1LMNAPOLB
SCHEMBL17502107 0.78 KMT2A (0.65) ALDH1A1LMNAGAACNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2744330-B1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS UNIV UTAH RES FOUND (US) 2020-07-15 — — EP disclosed
CN-110015984-A Substituted (E)-N '-(1- phenylethylene) benzoyl hydrazine analog as histone demethylase inhibitor 犹他大学研究基金会 2019-07-16 — — CN disclosed
EP-3010915-B1 SUBSTITUTED (3-(5-CHLORO-2-HYDROXYPHENYL)-1-BENZOYL-1H-PYRAZOLE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS UNIV UTAH RES FOUND (US) 2019-05-08 — — EP disclosed
CN-105555784-B Substituted (E) -N' - (1-phenylethylene) benzoyl hydrazine analogs as histone demethylase inhibitors 犹他大学研究基金会 2019-03-15 — — CN disclosed
US-9642857-B2 Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2017-05-09 — — US disclosed
US-9555024-B2 Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2017-01-31 — — US disclosed
US-20160120875-A1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS UNIV UTAH RES FOUND (US) 2016-05-05 — — US disclosed
EP-3010915-A1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS University of Utah Research Foundation (US) 2016-04-27 — — EP disclosed
US-9266838-B2 Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2016-02-23 — — US disclosed
US-20150150864-A1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2015-06-04 — — US disclosed
US-8987335-B2 Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2015-03-24 — — US disclosed
WO-2014205213-A1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2014-12-24 — — WO disclosed
CN-103929960-A Substituted -N' - (1-phenylethylidene) benzoyl hydrazine analogs as histone demethylase inhibitors UNIV UTAH RES FOUND 2014-07-16 — — CN disclosed
EP-2744330-A1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS University Of Utah Research Foundation (US) 2014-06-25 — — EP disclosed
US-20140163017-A1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS UNIVERSITY OF UTAH (US) 2014-06-12 — — US disclosed
WO-2013025805-A1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2013-02-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150150864-A1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM1A, DOT1L HSD17B10 984/4885CA1 2649/4885CA2 2622/4885
US-20140163017-A1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM1A, DOT1L HSD17B10 984/4885CA1 2649/4885CA2 2622/4885
US-20160120875-A1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS DOT1L, NSD1, KDM1B HSD17B10 1481/4885CA1 4143/4885CA2 4235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.