Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 10/20 | 0.39 |
| ▸ | JAK3 | P52333 | 10/20 | 0.39 |
| ▸ | JAK1 | P23458 | 9/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240387 | 0.78 | PARP1 (0.37) | DYRK1AJAK2JAK3JAK1 | |
| SCHEMBL4352565 | 0.76 | NUDT1 (0.47) | PRKCIAXLDYRK1AJAK2JAK3 | |
| SCHEMBL2318359 | 0.75 | CCNK (0.46) | PRKCIAXLDYRK1AJAK2JAK3 | |
| SCHEMBL14697441 | 0.73 | CCR8 (0.52) | PRKCIAXLDYRK1AJAK2JAK3 | |
| SCHEMBL2316792 | 0.72 | JAK2 (0.45) | PRKCIAXLDYRK1AJAK2JAK3 | |
| SCHEMBL14697181 | 0.71 | TYMP (0.49) | PRKCIAXLDYRK1AJAK2JAK3 | |
| SCHEMBL25278009 | 0.70 | KDM4E (0.50) | — | |
| SCHEMBL29588095 | 0.70 | PRKCI (0.42) | PRKCIAXLDYRK1AJAK2JAK3 | |
| SCHEMBL17353634 | 0.70 | PRKCI (0.42) | PRKCIAXLDYRK1AJAK2JAK3 | |
| Hydrochloric Acid SCHEMBL14697453 | 0.70 | TYMP (0.47) | PRKCIAXLDYRK1AJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2742049-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AND JAK INHIBITORS | Nissan Chemical Industries, Ltd. (JP) | 2014-06-18 | — | — | EP | disclosed |
| WO-2013024895-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AND JAK INHIBITORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-02-21 | — | — | WO | disclosed |