Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 20/20 | 0.49 |
| ▸ | INSR | P06213 | 9/20 | 0.49 |
| ▸ | TEC | P42680 | 1/20 | 0.47 |
| ▸ | TXK | P42681 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14708840 | 0.87 | ITK (0.53) | ITKINSRTECTXKCHEK2 | |
| SCHEMBL14708837 | 0.87 | ITK (0.53) | ITKINSRTECTXKCHEK2 | |
| SCHEMBL14708988 | 0.83 | ITK (0.64) | ITKINSRTECTXKCHEK2 | |
| SCHEMBL6274413 | 0.81 | ITK (0.39) | ITKINSR | |
| SCHEMBL14708857 | 0.81 | ITK (0.46) | ITKINSR | |
| SCHEMBL14708876 | 0.81 | ITK (0.39) | ITKINSR | |
| SCHEMBL5576415 | 0.81 | ITK (0.69) | ITKINSRCHEK2NTRK1PRKCG | |
| SCHEMBL14698057 | 0.81 | ITK (0.53) | ITKINSRTECTXKCHEK2 | |
| SCHEMBL21310889 | 0.80 | BACE1 (0.39) | ITKINSR | |
| SCHEMBL6277070 | 0.79 | ALDH1A1 (0.38) | ITKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013024427-A1 | NOVEL UREA DERIVATIVES AS TEC KINASE INHIBITORS AND USES THEREOF | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-02-21 | — | — | WO | disclosed |