Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.89 |
| ▸ | DRD3 | P35462 | 11/20 | 0.89 |
| ▸ | DRD4 | P21917 | 8/20 | 0.89 |
| ▸ | DRD1 | P21728 | 5/20 | 0.89 |
| ▸ | HTR1A | P08908 | 2/20 | 0.89 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.89 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.89 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.89 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.89 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.89 |
| ▸ | CNR1 | P21554 | 1/20 | 0.89 |
| ▸ | ACHE | P22303 | 1/20 | 0.89 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.89 |
| ▸ | HTR2A | P28223 | 1/20 | 0.89 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.89 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.89 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.89 |
| ▸ | HRH1 | P35367 | 1/20 | 0.89 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.89 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14696824 | 1.00 | DRD2 (0.89) | DRD2DRD3DRD4DRD1HTR1A | |
| Rotigotine SCHEMBL1088585 | 0.94 | DRD2 (1.00) | DRD2DRD3DRD4DRD1HTR1A | |
| Rotigotine SCHEMBL30200958 | 0.94 | DRD2 (1.00) | DRD2DRD3DRD4DRD1HTR1A | |
| Rotigotine SCHEMBL9405994 | 0.94 | DRD2 (1.00) | DRD2DRD3DRD4DRD1HTR1A | |
| Rotigotine SCHEMBL50425 | 0.94 | DRD2 (1.00) | DRD2DRD3DRD4DRD1HTR1A | |
| Rotigotine SCHEMBL29354493 | 0.94 | DRD2 (1.00) | DRD2DRD3DRD4DRD1HTR1A | |
| Rotigotine SCHEMBL15970012 | 0.94 | DRD2 (0.98) | DRD2DRD3DRD4DRD1HTR1A | |
| Rotigotine SCHEMBL2597403 | 0.94 | DRD2 (0.98) | DRD2DRD3DRD4DRD1HTR1A | |
| Rotigotine SCHEMBL2597402 | 0.94 | DRD2 (0.98) | DRD2DRD3DRD4DRD1HTR1A | |
| Rotigotine SCHEMBL30730591 | 0.94 | DRD2 (0.98) | DRD2DRD3DRD4DRD1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117007707-A | Improved detection method for impurities in rotigotine | 北京泰德制药股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| EP-2744801-B1 | 5,6,7,8-TETRAHYDRO-6-[N,N-BIS[(2-THIENYL)ETHYL]]AMINO-1-NAPHTHOL, AND PREPARING METHOD AND USE THEREOF | SHAN DONG LUYE PHARM CO LTD (CN) | 2017-02-15 | — | — | EP | disclosed |
| US-9012660-B2 | 5,6,7,8-tetrahydro-6-[N,N-bis[(2-thienyl)ethyl]] amino-1-naphthol, and preparing method and use thereof | SHANDONG LUYE PHARMACEUTICAL CO., LTD. (CN) | 2015-04-21 | — | — | US | disclosed |
| EP-2744801-A1 | 5,6,7,8-TETRAHYDRO-6-[N,N-BIS[(2-THIENYL)ETHYL]]AMINO-1-NAPHTHOL, AND PREPARING METHOD AND USE THEREOF | Shan Dong Luye Pharmaceutical Co., Ltd. (CN) | 2014-06-25 | — | — | EP | disclosed |
| WO-2013023433-A1 | 5,6,7,8-TETRAHYDRO-6-[N,N-BIS[(2-THIENYL)ETHYL]]AMINO-1-NAPHTHOL, AND PREPARING METHOD AND USE THEREOF | SHANDONG LUYE PHARMACEUTICAL CO., LTD (CN) | 2013-02-21 | — | — | WO | disclosed |