Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 10/20 | 0.43 |
| ▸ | MERTK | Q12866 | 9/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58983 | 0.91 | RET (0.46) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL59327 | 0.83 | RET (0.46) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL66922 | 0.82 | RET (0.45) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL58840 | 0.82 | TYRO3 (0.52) | TYRO3MERTKAXLACVRL1 | |
| Hydrochloric Acid SCHEMBL58938 | 0.82 | RET (0.45) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL27768250 | 0.81 | TYRO3 (0.46) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL59020 | 0.80 | TYRO3 (0.51) | TYRO3MERTKAXL | |
| SCHEMBL58402 | 0.80 | RET (0.45) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL58916 | 0.80 | RET (0.52) | TYRO3MERTKAXLACVRL1 | |
| SCHEMBL58193 | 0.80 | RET (0.52) | TYRO3MERTKAXLACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-B1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2013-02-13 | — | — | EP | disclosed |