Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 10/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | FRK | P42685 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.46 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 6/20 | 0.44 |
| ▸ | AXL | P30530 | 4/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58840 | 0.94 | TYRO3 (0.52) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL5036616 | 0.94 | RET (0.52) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL58402 | 0.93 | RET (0.45) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL59327 | 0.92 | RET (0.46) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL59020 | 0.92 | TYRO3 (0.51) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL58287 | 0.92 | RET (0.46) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL60139 | 0.91 | RET (0.47) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL28776688 | 0.91 | TYRO3 (0.54) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL58983 | 0.91 | RET (0.46) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL60070 | 0.91 | RIPK1 (0.49) | TYRO3RETFGFR1FLT3FRK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | claimed |
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |