Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14704024 | 0.87 | NTRK1 (0.38) | TAS1R3TAS1R1TAS1R2NTRK1GSK3B | |
| SCHEMBL14704051 | 0.87 | NTRK1 (0.38) | TAS1R3TAS1R1TAS1R2NTRK1GSK3B | |
| SCHEMBL12443623 | 0.86 | CNR1 (0.40) | NTRK1GSK3BDYRK1AKDM5AGRM2 | |
| SCHEMBL4988236 | 0.80 | GSK3B (0.37) | NTRK1GSK3BDYRK1AKDM5AGRM2 | |
| SCHEMBL1662858 | 0.77 | BAZ2B (0.46) | NTRK1GSK3BDYRK1AKDM5AGRM2 | |
| SCHEMBL3301735 | 0.75 | XIAP (0.36) | NTRK1GSK3BDYRK1AKDM5AGRM2 | |
| SCHEMBL17518681 | 0.75 | GSK3B (0.42) | NTRK1GSK3BDYRK1AKDM5AGRM2 | |
| SCHEMBL26605437 | 0.75 | GSK3B (0.40) | NTRK1GSK3BDYRK1AKDM5AGRM2 | |
| SCHEMBL12911102 | 0.75 | P2RX7 (0.42) | NTRK1GSK3BDYRK1AKDM5AGRM2 | |
| SCHEMBL4988751 | 0.74 | GRM2 (0.37) | NTRK1GSK3BDYRK1AKDM5AGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284350-B2 | IAP BIR domain binding compounds | PHARMASCIENCE INC. (CA) | 2016-03-15 | — | — | US | disclosed |
| US-20130040892-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | PHARMASCIENCE INC. (CA) | 2013-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040892-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | BIRC5, BIRC2, BIRC3 | TAS1R3 3272/4885TAS1R1 2326/4885TAS1R2 3742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.