⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2262348 | 0.72 | — | — | |
| SCHEMBL20032246 | 0.72 | TSHR (0.35) | — | |
| SCHEMBL8432274 | 0.69 | — | — | |
| SCHEMBL13901138 | 0.69 | — | — | |
| SCHEMBL9123 | 0.67 | — | — | |
| SCHEMBL4952330 | 0.67 | CES2 (0.32) | — | |
| SCHEMBL4909891 | 0.67 | — | — | |
| SCHEMBL3417774 | 0.67 | — | — | |
| SCHEMBL29032038 | 0.67 | TSHR (0.32) | — | |
| SCHEMBL10013988 | 0.67 | TSHR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9833455-B2 | Preparation and methods of use for ortho-aryl 5-membered heteroaryl-carboxamide containing multi-targeted kinase inhibitors | SPACEFILL ENTERPRISES LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-20160303128-A1 | PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5-MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS | VIBLIOME THERAPEUTICS, LLC | 2016-10-20 | — | — | US | disclosed |
| US-20160303128-A1 | PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5-MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS | VIBLIOME THERAPEUTICS, LLC | 2016-10-20 | — | — | US | disclosed |
| US-9221805-B2 | Preparation and methods of use for ortho-aryl 5-membered heteroaryl-carboxamide containing multi-targeted kinase inhibitors | Spacefill Enterprises LLP (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221805-B2 | Preparation and methods of use for ortho-aryl 5-membered heteroaryl-carboxamide containing multi-targeted kinase inhibitors | Spacefill Enterprises LLP (US) | 2015-12-29 | — | — | US | disclosed |
| US-9090583-B2 | Benzopyrone estrogen receptor regulator | BEIJING SHENOGEN PHARMA GROUP LTD. (CN) | 2015-07-28 | — | — | US | disclosed |
| US-9090583-B2 | Benzopyrone estrogen receptor regulator | BEIJING SHENOGEN PHARMA GROUP LTD. (CN) | 2015-07-28 | — | — | US | disclosed |
| US-20140228367-A1 | PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5-MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS | VIBLIOME THERAPEUTICS, LLC | 2014-08-14 | — | — | US | disclosed |
| US-20140228367-A1 | PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5-MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS | VIBLIOME THERAPEUTICS, LLC | 2014-08-14 | — | — | US | disclosed |
| US-20130303544-A1 | BENZOPYRONE ESTROGEN RECEPTOR REGULATOR | BEIJING SHENOGEN PHARMA GROUP LTD. (CN) | 2013-11-14 | — | — | US | disclosed |
| US-20130303544-A1 | BENZOPYRONE ESTROGEN RECEPTOR REGULATOR | BEIJING SHENOGEN PHARMA GROUP LTD. (CN) | 2013-11-14 | — | — | US | disclosed |
| EP-2660240-A1 | BENZOPYRONE ESTROGEN RECEPTOR REGULATOR | Beijing Shenogen Pharma Group Ltd. (CN) | 2013-11-06 | — | — | EP | disclosed |
| WO-2013022766-A1 | PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5- MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS | FLYNN GARY A (US) | 2013-02-14 | — | — | WO | disclosed |