SCHEMBL14707902

SCHEMBL14707902

COc1cc(C)ccc1NC(=O)Cn1c(=O)n(Cc2ncco2)c(=O)c2sc3ccccc3c21

nearest known ligand 0.66

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ RXFP1 Q9HBX9 8/20 0.66
▸ TP53 P04637 11/20 0.63
▸ MAPT P10636 7/20 0.62
▸ TDP1 Q9NUW8 1/20 0.58
▸ POLB P06746 3/20 0.55
▸ THRB P10828 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12285304 0.93 RXFP1 (0.77) RXFP1TP53MAPTTDP1POLB
SCHEMBL14707899 0.88 RXFP1 (0.64) RXFP1TP53MAPTTDP1POLB
SCHEMBL14707908 0.88 MAPT (0.65) RXFP1TP53MAPTTDP1POLB
SCHEMBL14707913 0.86 RXFP1 (0.63) RXFP1TP53MAPTTDP1POLB
SCHEMBL14707909 0.85 MAPT (0.62) RXFP1TP53MAPTTDP1POLB
SCHEMBL14707900 0.85 MAPT (0.62) RXFP1TP53MAPTTDP1POLB
SCHEMBL14707907 0.85 RXFP1 (0.65) RXFP1TP53MAPTTDP1POLB
SCHEMBL14707914 0.85 MAPT (0.67) RXFP1TP53MAPTTDP1POLB
SCHEMBL14707916 0.84 MAPT (0.69) RXFP1TP53MAPTTDP1POLB
SCHEMBL14707903 0.84 MAPT (0.63) RXFP1TP53MAPTTDP1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8927561-B2 Pyrimidinedione anti-viral compounds Kineta, Inc. (US) 2015-01-06 — — US disclosed
US-20130045229-A1 Anti-Viral Compounds Kineta, Inc. (US) 2013-02-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130045229-A1 Anti-Viral Compounds MAVS, EIF2AK2, IRF3 RXFP1 3056/4885TP53 1338/4885MAPT 3520/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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