Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Argatroban. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 7/20 | 0.82 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.77 |
| ▸ | F10 | P00742 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | PLAT | P00750 | 1/20 | 0.77 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.77 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Argatroban SCHEMBL23356536 | 1.00 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL7279618 | 1.00 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1133728 | 1.00 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL29501077 | 1.00 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL3447908 | 1.00 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL4374 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1817517 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL4933701 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL3175687 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1145308 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099706-A1 | ARGATROBAN FORMULATION | BAXTER INTERNATIONAL INC. (US) | 2010-04-22 | — | — | US | claimed |
| US-20100099705-A1 | ARGATROBAN FORMULATION | BAXTER INTERNATIONAL INC. (US) | 2010-04-22 | — | — | US | claimed |
| US-7642271-B2 | Argatroban formulation | BAXTER INTERNATIONAL INC. (US) | 2010-01-05 | — | — | US | claimed |
| EP-1948133-A2 | ARGATROBAN FORMULATION COMPRISING AN ACID AS SOLUBILIZER | BAXTER INTERNATIONAL INC. (a Delaware corporation) (US) | 2008-07-30 | — | — | EP | claimed |
| WO-2007027565-A2 | ARGATROBAN FORMULATION COMPRISING AN ACID AS SOLUBILIZER | BAXTER INTERNATIONAL INC. (US) | 2007-03-08 | — | — | WO | claimed |
| US-20070049617-A1 | Argatroban formulation | BAXTER INTERNATIONAL INC. | 2007-03-01 | — | — | US | claimed |
| US-8034830-B2 | Argatroban formulation | BAXTER INTERNATIONAL INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-7985757-B2 | Argatroban formulation | BAXTER INTERNATIONAL INC. (US) | 2011-07-26 | — | — | US | disclosed |
| US-7915290-B2 | Argatroban formulations and methods for making and using same | BAXTER INTERNATIONAL INC. (US) | 2011-03-29 | — | — | US | disclosed |
| US-20100099705-A1 | ARGATROBAN FORMULATION | BAXTER INTERNATIONAL INC. (US) | 2010-04-22 | — | — | US | disclosed |
| US-20100099706-A1 | ARGATROBAN FORMULATION | BAXTER INTERNATIONAL INC. (US) | 2010-04-22 | — | — | US | disclosed |
| US-7642271-B2 | Argatroban formulation | BAXTER INTERNATIONAL INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-20090221636-A1 | ARGATROBAN FORMULATIONS AND METHODS FOR MAKING AND USING SAME | BAXTER INTERNATIONAL INC. (US) | 2009-09-03 | — | — | US | disclosed |
| US-20090221637-A1 | SOLID-STATE SALT ARGATROBAN FORMULATIONS AND METHODS FOR PRODUCING AND USING THE SAME | BAXTER INTERNATIONAL INC. (US) | 2009-09-03 | — | — | US | disclosed |
| EP-1948133-A2 | ARGATROBAN FORMULATION COMPRISING AN ACID AS SOLUBILIZER | BAXTER INTERNATIONAL INC. (a Delaware corporation) (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007027565-A2 | ARGATROBAN FORMULATION COMPRISING AN ACID AS SOLUBILIZER | BAXTER INTERNATIONAL INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| US-20070049617-A1 | Argatroban formulation | BAXTER INTERNATIONAL INC. | 2007-03-01 | — | — | US | disclosed |
| WO-2006019894-A2 | NEBULIZED PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF BRONCHIAL DISORDERS | O'CONNOR MICHAEL F (US) | 2006-02-23 | — | — | WO | disclosed |
| US-20060014698-A1 | Nebulized pharmaceutical compositions for the treatment of bronchial disorders | O'CONNOR MICHAEL F | 2006-01-19 | — | — | US | disclosed |