Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Argatroban. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 7/20 | 0.82 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.77 |
| ▸ | F10 | P00742 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | PLAT | P00750 | 1/20 | 0.77 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.77 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Argatroban SCHEMBL7279618 | 1.00 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1133728 | 1.00 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL29501077 | 1.00 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1470919 | 1.00 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL3447908 | 1.00 | F2 (0.82) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL4374 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1817517 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL4933701 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL3175687 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1145308 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101235031-A | Directional synthesis and crystal structure of 21 argatroban and preparation of monohydrate | TIANJIN WEIJIE TECHNOLOGY CO L (CN) | 2008-08-06 | — | — | CN | claimed |
| WO-2021093374-A1 | METHOD FOR SYNTHESIZING ARGATROBAN HYDRATE | 山东新时代药业有限公司 | 2021-05-20 | — | — | WO | disclosed |
| CN-101914133-B | Directional synthesis method for 21(S) argatroban | TIANJIN WEIJIE TECHNOLOGY CO LTD | 2013-01-30 | — | — | CN | disclosed |
| CN-101914133-A | Directional synthesis method for 21(S) argatroban | TIANJIN WEIJIE TECHNOLOGY CO LTD | 2010-12-15 | — | — | CN | disclosed |
| CN-101914132-A | Crystal structure of 21(S) argatroban | TIANJIN WEIJIE TECHNOLOGY CO LTD | 2010-12-15 | — | — | CN | disclosed |
| CN-100427480-C | Process for preparing argatroban hydrate | TIANJIN WEIJIE TECHNOLOGY CO L (CN) | 2008-10-22 | — | — | CN | disclosed |
| CN-101235031-A | Directional synthesis and crystal structure of 21 argatroban and preparation of monohydrate | TIANJIN WEIJIE TECHNOLOGY CO L (CN) | 2008-08-06 | — | — | CN | disclosed |
| CN-1951937-A | Process for preparing argatroban hydrate | TIANJIN WEIJIE TECHNOLOGY CO L (CN) | 2007-04-25 | — | — | CN | disclosed |