Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 11/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 10/20 | 1.00 |
| ▸ | MEN1 | O00255 | 9/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.76 |
| ▸ | NPC1 | O15118 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 12/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.68 |
| ▸ | USP2 | O75604 | 2/20 | 0.68 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10085969 | 0.88 | KMT2A (0.87) | GAAKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL10086015 | 0.86 | KMT2A (0.84) | GAAKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL4159123 | 0.84 | KMT2A (0.74) | GAAKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11288124 | 0.82 | GAA (0.70) | GAAKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11276978 | 0.82 | GAA (0.70) | GAAKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL3395971 | 0.82 | KMT2A (1.00) | GAAKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11279534 | 0.81 | KMT2A (0.74) | GAAKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11874703 | 0.81 | KMT2A (0.74) | GAAKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL10084915 | 0.81 | GAA (0.74) | GAAKMT2AMEN1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL11862709 | 0.80 | KMT2A (0.97) | GAAKMT2AMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013023300-A1 | INHIBITORS OF ANDROGEN RECEPTOR ACTIVATION FUNCTION-2 (AF2) AS THERAPEUTICS AND METHODS FOR THEIR USE | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2013-02-21 | — | — | WO | disclosed |