Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 7/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | ABL2 | P42684 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK17 | Q00537 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2630210 | 1.00 | CTSS (0.42) | CTSSJAK3PLK4JAK2ROCK2 | |
| SCHEMBL10037014 | 1.00 | CTSS (0.42) | CTSSJAK3PLK4JAK2ROCK2 | |
| SCHEMBL2630208 | 1.00 | CTSS (0.42) | CTSSJAK3PLK4JAK2ROCK2 | |
| SCHEMBL2630176 | 0.92 | CTSS (0.42) | CTSSJAK3PLK4JAK2ROCK2 | |
| SCHEMBL2630160 | 0.92 | CTSS (0.42) | CTSSJAK3PLK4JAK2ROCK2 | |
| SCHEMBL2630123 | 0.92 | CTSS (0.42) | CTSSJAK3PLK4JAK2ROCK2 | |
| SCHEMBL2630246 | 0.91 | CTSS (0.40) | CTSSJAK3PLK4JAK2ROCK2 | |
| SCHEMBL2630143 | 0.90 | CTSS (0.40) | CTSSJAK3PLK4JAK2ROCK2 | |
| SCHEMBL2630146 | 0.90 | CTSS (0.40) | CTSSJAK3PLK4JAK2ROCK2 | |
| SCHEMBL2630178 | 0.90 | CTSS (0.40) | CTSSJAK3PLK4JAK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2559694-A2 | Azaindoles useful as inhibitors of Janus kinases | Vertex Pharmaceuticals, Inc. (US) | 2013-02-20 | — | — | EP | disclosed |