Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14327614 | 0.89 | CLK4 (0.46) | JAK2JAK3CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL2633664 | 0.86 | JAK2 (0.52) | JAK2JAK3CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL8941812 | 0.85 | CLK4 (0.53) | JAK2JAK3CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL14327593 | 0.84 | JAK2 (0.52) | JAK2JAK3CYP3A4CYP2D6CLK4 | |
| SCHEMBL2630148 | 0.81 | JAK3 (0.49) | JAK2JAK3CYP3A4CDK9CDK2 | |
| SCHEMBL14465248 | 0.81 | CYP1A2 (0.44) | JAK2JAK3CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL2630395 | 0.81 | JAK3 (0.45) | JAK2JAK3CDK9PLK4ROCK2 | |
| SCHEMBL2630273 | 0.80 | JAK3 (0.61) | JAK2JAK3CYP3A4CDK9PLK4 | |
| SCHEMBL2630105 | 0.79 | JAK3 (0.40) | JAK2JAK3CDK9PLK4ROCK2 | |
| SCHEMBL10037012 | 0.79 | JAK3 (0.40) | JAK2JAK3CDK9PLK4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2559694-A2 | Azaindoles useful as inhibitors of Janus kinases | Vertex Pharmaceuticals, Inc. (US) | 2013-02-20 | — | — | EP | disclosed |