Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1477714 | 0.85 | HTR2C (0.54) | NR1H2NR1H3HTR2AHTR2CHTR2B | |
| SCHEMBL4419012 | 0.80 | KCNK3 (0.46) | NR1H2NR1H3KMT2AKCNK3 | |
| SCHEMBL2075830 | 0.72 | HTR2A (0.56) | HTR2AHTR2CHTR2B | |
| SCHEMBL3087986 | 0.69 | NR1H2 (0.50) | NR1H2NR1H3KMT2AMEN1ALDH1A1 | |
| SCHEMBL1407196 | 0.68 | NR1H2 (0.75) | NR1H2NR1H3KMT2AMEN1 | |
| SCHEMBL1476313 | 0.68 | HTR2C (0.51) | NR1H2NR1H3KCNK3HTR2AHTR2C | |
| SCHEMBL2076319 | 0.68 | HTR7 (0.73) | KCNK3HTR2AHTR2CHTR2B | |
| SCHEMBL1477936 | 0.68 | HTR2C (0.53) | HTR2AHTR2CHTR2B | |
| SCHEMBL1475046 | 0.67 | HTR2A (0.65) | NR1H2NR1H3HTR2AHTR2CHTR2B | |
| SCHEMBL1407811 | 0.66 | NR1H2 (0.57) | NR1H2NR1H3KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1905774-B1 | Fused heterocyclic compounds as serotonin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-20 | — | — | EP | disclosed |