Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 13/20 | 0.82 |
| ▸ | AURKA | O14965 | 4/20 | 0.67 |
| ▸ | SCD | O00767 | 2/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | WNT1 | P04628 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16163138 | 0.91 | ITK (0.82) | ITKAURKASCDKLKB1DYRK1A | |
| SCHEMBL14699075 | 0.90 | ITK (1.00) | ITKAURKASCDKLKB1 | |
| SCHEMBL14712459 | 0.89 | ITK (0.80) | ITKAURKASCDLRRK2WNT1 | |
| SCHEMBL16163079 | 0.89 | ITK (0.68) | ITKAURKASCDTAS2R8LRRK2 | |
| SCHEMBL14712457 | 0.88 | ITK (0.78) | ITKAURKASCD | |
| SCHEMBL16163005 | 0.86 | ITK (0.68) | ITKAURKASCDKLKB1TAS2R8 | |
| SCHEMBL14699225 | 0.84 | ITK (0.83) | ITKAURKASCDTAS2R8LRRK2 | |
| SCHEMBL14699387 | 0.83 | ITK (0.81) | ITKAURKASCDKLKB1TAS2R8 | |
| SCHEMBL14699049 | 0.82 | ITK (0.76) | ITKAURKASCDKLKB1TAS2R8 | |
| SCHEMBL14699412 | 0.81 | ITK (1.00) | ITKAURKASCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2742040-B1 | INDAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2016-04-06 | — | — | EP | disclosed |
| EP-2742040-B1 | INDAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2016-04-06 | — | — | EP | disclosed |
| US-20140309210-A1 | INDAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-10-16 | — | — | US | disclosed |
| US-20140309210-A1 | INDAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-10-16 | — | — | US | disclosed |
| WO-2013024011-A1 | INDAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309210-A1 | INDAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | CYP3A43, INSR, CYP2C19 | ITK 1578/4885AURKA 2633/4885SCD 4513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.