Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 11/20 | 0.66 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.46 |
| ▸ | GSK3B | P49841 | 6/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | WNT1 | P04628 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16163138 | 0.90 | ITK (0.82) | ITKAURKADYRK1AGSK3BCLK2 | |
| SCHEMBL14712461 | 0.81 | ITK (0.82) | ITKAURKADYRK1ACLK2CLK3 | |
| SCHEMBL14712554 | 0.81 | ITK (0.68) | ITKAURKADYRK1AGSK3BCLK2 | |
| SCHEMBL14712581 | 0.80 | ITK (0.66) | ITKAURKADYRK1AGSK3BCLK2 | |
| SCHEMBL14699075 | 0.80 | ITK (1.00) | ITKAURKASCD | |
| SCHEMBL14712458 | 0.79 | ITK (0.54) | ITKAURKADYRK1ACLK2CLK3 | |
| SCHEMBL14712558 | 0.79 | ITK (0.69) | ITKAURKADYRK1AGSK3BCLK2 | |
| SCHEMBL14712557 | 0.79 | ITK (0.80) | ITKAURKADYRK1ACLK2CLK3 | |
| SCHEMBL14712429 | 0.78 | ITK (0.64) | ITKAURKADYRK1AWNT1 | |
| SCHEMBL14712407 | 0.78 | ITK (0.61) | ITKAURKASCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013024011-A1 | INDAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-21 | — | — | WO | disclosed |