Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835395 | 0.90 | KDR (0.53) | KDRPDGFRBPTGS2 | |
| SCHEMBL1478198 | 0.89 | KDR (0.51) | KDRPDGFRBSLC16A3 | |
| SCHEMBL835809 | 0.89 | KDR (0.46) | KDRPDGFRBHTT | |
| SCHEMBL14713129 | 0.88 | KDR (0.53) | KDRPDGFRBPTGS2LMNA | |
| SCHEMBL834977 | 0.88 | KDR (0.46) | KDRPDGFRBPTGS2ALDH1A1LMNA | |
| SCHEMBL835745 | 0.88 | KDR (0.43) | KDRPDGFRBPTGS2SLC16A3ALDH1A1 | |
| SCHEMBL832320 | 0.88 | KDR (0.46) | KDRPDGFRBPTGS2ALDH1A1HTT | |
| SCHEMBL836330 | 0.87 | KDR (0.49) | KDRPDGFRBLMNA | |
| SCHEMBL836693 | 0.87 | KDR (0.45) | KDRPDGFRBPTGS2SLC16A3 | |
| SCHEMBL835442 | 0.87 | KDR (0.47) | KDRPDGFRBSLC16A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099757-B1 | SULFOXIMINES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| US-8383825-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2013-02-26 | — | — | US | disclosed |