Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL834579 | 0.92 | KDR (0.57) | KDRPDGFRBPTGS2EGFRLMNA | |
| SCHEMBL14713211 | 0.90 | KDR (0.48) | KDRPDGFRBPTGS2 | |
| SCHEMBL14713166 | 0.89 | KDR (0.44) | KDRPDGFRBPTGS2EGFRLMNA | |
| SCHEMBL833427 | 0.89 | KDR (0.47) | KDRPDGFRBPTGS2EGFRMAPT | |
| SCHEMBL14713153 | 0.88 | KDR (0.45) | KDRPDGFRBPTGS2LMNA | |
| SCHEMBL835338 | 0.88 | KDR (0.54) | KDRPDGFRBPTGS2EGFRLMNA | |
| SCHEMBL11907861 | 0.87 | KDR (0.42) | KDRPDGFRBLMNAMAPTF2 | |
| SCHEMBL835068 | 0.87 | KDR (0.51) | KDRPDGFRBPTGS2EGFRLMNA | |
| SCHEMBL14713170 | 0.87 | KDR (0.57) | KDRPDGFRB | |
| SCHEMBL836563 | 0.87 | KDR (0.55) | KDRPDGFRBPTGS2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099757-B1 | SULFOXIMINES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2014-06-25 | — | — | EP | disclosed |
| US-8383825-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2013-02-26 | — | — | US | disclosed |