Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | WHR1 | P49842 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 6/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170445 | 0.88 | PDGFRB (0.40) | PDGFRBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14715376 | 0.86 | WHR1 (0.46) | WHR1 | |
| SCHEMBL14715442 | 0.86 | WHR1 (0.44) | WHR1 | |
| SCHEMBL14715298 | 0.86 | WHR1 (0.44) | WHR1 | |
| SCHEMBL14715474 | 0.86 | MCHR1 (0.36) | RET | |
| SCHEMBL14715424 | 0.83 | WHR1 (0.42) | WHR1RET | |
| SCHEMBL14715403 | 0.83 | WHR1 (0.41) | PDGFRBWHR1RET | |
| SCHEMBL14715369 | 0.82 | PDE5A (0.44) | WHR1 | |
| SCHEMBL14715513 | 0.82 | NPC1 (0.41) | RET | |
| SCHEMBL14715414 | 0.81 | NPC1 (0.41) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346848-B1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |