Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | WHR1 | P49842 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715376 | 0.93 | WHR1 (0.46) | WHR1ADRA1AADRA1B | |
| SCHEMBL14715512 | 0.92 | ADRA1A (0.51) | ADRA1AADRA1B | |
| SCHEMBL14715298 | 0.88 | WHR1 (0.44) | WHR1ADRA1AADRA1B | |
| SCHEMBL14715442 | 0.88 | WHR1 (0.44) | WHR1ADRA1AADRA1B | |
| SCHEMBL2170268 | 0.88 | PDGFRB (0.45) | PDGFRBPDGFRAALDH1A1KDM4EMAPK1 | |
| SCHEMBL14715403 | 0.88 | WHR1 (0.41) | PDGFRBWHR1ADRA1AADRA1B | |
| SCHEMBL14715424 | 0.87 | WHR1 (0.42) | WHR1ADRA1AADRA1B | |
| SCHEMBL14715369 | 0.87 | PDE5A (0.44) | WHR1 | |
| SCHEMBL14715456 | 0.85 | WHR1 (0.39) | WHR1ADRA1AADRA1B | |
| SCHEMBL14715262 | 0.84 | ADRA1A (0.56) | ALDH1A1KDM4EMAPK1MAPTADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346848-B1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |