Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.57 |
| ▸ | LCK | P06239 | 7/20 | 0.57 |
| ▸ | KDR | P35968 | 7/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.57 |
| ▸ | JAK3 | P52333 | 3/20 | 0.52 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 4/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | CCNK | O75909 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | CDK7 | P50613 | 3/20 | 0.47 |
| ▸ | CCNH | P51946 | 3/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14568018 | 1.00 | MAPK14 (0.57) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5496356 | 0.91 | RIPK2 (0.60) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5496640 | 0.87 | MAPK14 (0.56) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL14724605 | 0.86 | MAPK14 (0.65) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5488807 | 0.85 | MAPK14 (0.75) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5491560 | 0.83 | MAPK14 (0.64) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5498153 | 0.83 | MAPK14 (0.67) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5497380 | 0.83 | MAPK14 (0.67) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5501168 | 0.83 | MAPK14 (0.61) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5500229 | 0.83 | MAPK14 (0.61) | MAPK14LCKKDRKITMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |