Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.56 |
| ▸ | LCK | P06239 | 5/20 | 0.56 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | CCNK | O75909 | 7/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.46 |
| ▸ | CDK2 | P24941 | 7/20 | 0.46 |
| ▸ | CDK7 | P50613 | 7/20 | 0.46 |
| ▸ | CCNH | P51946 | 7/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.46 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715468 | 0.87 | MAPK14 (0.57) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL14568018 | 0.87 | MAPK14 (0.57) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL14724605 | 0.84 | MAPK14 (0.65) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5491560 | 0.81 | MAPK14 (0.64) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5497380 | 0.81 | MAPK14 (0.67) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5498153 | 0.81 | MAPK14 (0.67) | MAPK14LCKKDRKITMAPK9 | |
| Bicarbonate SCHEMBL14715657 | 0.80 | MAPK14 (0.63) | MAPK14LCKKDRKITMAPK9 | |
| Bicarbonate SCHEMBL14715594 | 0.79 | MAPK14 (0.66) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL14715687 | 0.79 | MAPK14 (0.64) | MAPK14LCKKDRKITMAPK9 | |
| SCHEMBL5494427 | 0.79 | MAPK14 (0.64) | MAPK14LCKKDRKITMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | AMGEN INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | MAP3K1, MAP3K5, MAP3K2 | MAPK14 301/4885LCK 106/4885KDR 1044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.