Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | FER | P16591 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715504 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1MAPTNPSR1LRRK2 | |
| SCHEMBL6087481 | 0.82 | LRRK2 (0.42) | SMN1; SMN2ALDH1A1MAPTNPSR1LRRK2 | |
| SCHEMBL6087485 | 0.82 | LRRK2 (0.42) | SMN1; SMN2ALDH1A1MAPTNPSR1LRRK2 | |
| SCHEMBL6093666 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1MAPTNPSR1LRRK2 | |
| SCHEMBL6093668 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1MAPTNPSR1LRRK2 | |
| SCHEMBL14725083 | 0.76 | LRRK2 (0.39) | SMN1; SMN2ALDH1A1MAPTNPSR1LRRK2 | |
| SCHEMBL6086479 | 0.76 | LRRK2 (0.39) | SMN1; SMN2ALDH1A1MAPTNPSR1LRRK2 | |
| SCHEMBL6086475 | 0.76 | LRRK2 (0.39) | SMN1; SMN2ALDH1A1MAPTNPSR1LRRK2 | |
| SCHEMBL6086032 | 0.76 | LRRK2 (0.39) | SMN1; SMN2ALDH1A1LRRK2ACVR1PDGFRA | |
| SCHEMBL6086021 | 0.75 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1MAPTNPSR1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490356-B1 | (3Z)-3-(3-HYDRO-ISOBENZOFURAN-1-YLIDENE)-1,3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2013-02-27 | — | — | EP | claimed |