Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL3475263 | 0.96 | KDM4E (0.42) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL21230286 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| Benzene SCHEMBL1202117 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL3538383 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL3254218 | 0.81 | KDM4E (0.48) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL10435078 | 0.81 | KDM4E (0.48) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL1202477 | 0.79 | KDM4E (0.50) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL22853848 | 0.77 | L3MBTL1 (0.55) | KDM4EALDH1A1MAPTALOX15NPSR1 | |
| SCHEMBL28442896 | 0.76 | PLAU (0.37) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL29113201 | 0.75 | KDM4E (0.39) | KDM4EALDH1A1MAPTCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973886-B1 | PROKINETICIN 1 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-27 | — | — | EP | claimed |
| EP-3749664-A1 | COMPOUNDS WHICH CAUSE DEGRADATION OF EGFR, FOR USE AGAINST CANCER | F. Hoffmann-La Roche AG (CH) | 2020-12-16 | — | — | EP | disclosed |
| WO-2019149922-A1 | COMPOUNDS WHICH CAUSE DEGRADATION OF EGFR, FOR USE AGAINST CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2019-08-08 | — | — | WO | disclosed |