Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 5/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087742 | 0.94 | NTRK1 (0.40) | NTRK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL6087746 | 0.94 | NTRK1 (0.40) | NTRK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL6086859 | 0.88 | NTRK1 (0.42) | NTRK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL6086865 | 0.88 | NTRK1 (0.42) | NTRK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL6089592 | 0.85 | NTRK1 (0.41) | NTRK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL6089596 | 0.85 | NTRK1 (0.41) | NTRK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL6086558 | 0.83 | PIM1 (0.38) | NTRK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL6086555 | 0.83 | PIM1 (0.38) | NTRK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL6087838 | 0.82 | IMPDH2 (0.35) | KDM4EALDH1A1PKMMAPK14PGR | |
| SCHEMBL6087844 | 0.82 | IMPDH2 (0.35) | KDM4EALDH1A1PKMMAPK14PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490356-B1 | (3Z)-3-(3-HYDRO-ISOBENZOFURAN-1-YLIDENE)-1,3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2013-02-27 | — | — | EP | disclosed |