Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990820 | 0.90 | HPGD (0.41) | MCHR1HTTEPHX2HPGDRECQL | |
| SCHEMBL991456 | 0.87 | SIGMAR1 (0.47) | MEN1KMT2ASIGMAR1MCHR1NR1H4 | |
| SCHEMBL990289 | 0.75 | EPHX2 (0.53) | MEN1KMT2ASIGMAR1EPHX2SMN1; SMN2 | |
| SCHEMBL16390663 | 0.75 | EPHX2 (0.53) | MEN1KMT2ASIGMAR1EPHX2SMN1; SMN2 | |
| SCHEMBL990794 | 0.73 | MDM2 (0.41) | EPHX2HPGDTHRB | |
| SCHEMBL990846 | 0.72 | NPC1 (0.46) | KMT2ASIGMAR1EPHX2SMN1; SMN2 | |
| SCHEMBL990965 | 0.70 | GRM5 (0.44) | KMT2AEPHX2HPGDMAPTTHRB | |
| SCHEMBL991006 | 0.68 | GRM5 (0.46) | HPGD | |
| SCHEMBL992693 | 0.68 | GRM5 (0.46) | HPGD | |
| SCHEMBL990109 | 0.68 | GRM5 (0.42) | SIGMAR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130052644-A1 | Predictive Markers Useful in the Treatment of Fragile X Syndrome (FXS) | NOVARTIS AG (CH) | 2013-02-28 | — | — | US | disclosed |