SCHEMBL14720119

SCHEMBL14720119

COc1ccc(C(CN(C)C)C2(OF)CCCCC2)cc1

nearest known ligand 0.67

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 10/20 0.67
SLC6A4 P31645 10/20 0.67
SLC6A3 Q01959 8/20 0.67
LMNA P02545 1/20 0.67
CNR1 P21554 1/20 0.67
HTR2A P28223 1/20 0.67
HRH1 P35367 1/20 0.67
HRH3 Q9Y5N1 1/20 0.67
CACNA1F O60840 1/20 0.47
CACNA1D Q01668 1/20 0.47
CACNA1S Q13698 1/20 0.47
CACNA1C Q13936 1/20 0.47
OPRM1 P35372 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6392452 0.89 SLC6A2 (0.71) SLC6A2SLC6A4SLC6A3LMNACNR1
SCHEMBL16100233 0.86 SLC6A2 (0.71) SLC6A2SLC6A4SLC6A3LMNACNR1
SCHEMBL3994041 0.85 SLC6A2 (0.66) SLC6A2SLC6A4SLC6A3LMNACNR1
SCHEMBL8219545 0.83 SLC6A2 (0.63) SLC6A2SLC6A4SLC6A3LMNACNR1
SCHEMBL29091883 0.82 SLC6A2 (0.72) SLC6A2SLC6A4SLC6A3LMNACNR1
SCHEMBL12264394 0.82 SLC6A2 (0.72) SLC6A2SLC6A4SLC6A3LMNACNR1
SCHEMBL3059690 0.81 SLC6A2 (0.64) SLC6A2SLC6A4SLC6A3LMNACNR1
Hydrochloric Acid SCHEMBL6707673 0.81 SLC6A2 (0.66) SLC6A2SLC6A4SLC6A3LMNACNR1
Venlafaxine SCHEMBL1560692 0.81 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3LMNACNR1
SCHEMBL10616028 0.81 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3LMNACNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2744771-B1 C-HALOGEN BOND FORMATION UNIV PRINCETON (US) 2020-10-21 EP disclosed
US-20200190012-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2020-06-18 US disclosed
US-20190127311-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2019-05-02 US disclosed
US-10196341-B2 C-halogen bond formation THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2019-02-05 US disclosed
US-20160264512-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2016-09-15 US disclosed
WO-2015054476-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2015-04-16 WO disclosed
US-20150031768-A1 C-HALOGEN BOND FORMATION NATIONAL SCIENCE FOUNDATION 2015-01-29 US disclosed
US-20140249329-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2014-09-04 US disclosed
US-20140227184-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2014-08-14 US disclosed
EP-2744771-A1 C-HALOGEN BOND FORMATION The Trustees of Princeton University (US) 2014-06-25 EP disclosed
WO-2013081685-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2013-06-06 WO disclosed
WO-2013028639-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2013-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200190012-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 SLC6A2 3390/4885SLC6A4 3162/4885SLC6A3 740/4885
US-20140227184-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 SLC6A2 3390/4885SLC6A4 3162/4885SLC6A3 740/4885
US-20160264512-A1 C-HALOGEN BOND FORMATION FOS, BCL3, CBR3 SLC6A2 3906/4885SLC6A4 3469/4885SLC6A3 1489/4885
US-20190127311-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 SLC6A2 3390/4885SLC6A4 3162/4885SLC6A3 740/4885
US-20140249329-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 SLC6A2 3390/4885SLC6A4 3162/4885SLC6A3 740/4885
US-10196341-B2 C-halogen bond formation CBR3, FOS, CBR1 SLC6A2 3390/4885SLC6A4 3162/4885SLC6A3 740/4885
US-20150031768-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 SLC6A2 3390/4885SLC6A4 3162/4885SLC6A3 740/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.