Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978820 | 0.79 | CYP2D6 (0.39) | MAPK1 | |
| SCHEMBL16008684 | 0.77 | MAPK1 (0.36) | MAPK1 | |
| SCHEMBL29308168 | 0.77 | NR1H2 (0.43) | NR1H2MAPK1 | |
| SCHEMBL17715154 | 0.77 | NR1H2 (0.43) | NR1H2MAPK1 | |
| SCHEMBL934839 | 0.77 | NR1H2 (0.43) | NR1H2MAPK1 | |
| SCHEMBL17715141 | 0.77 | NR1H2 (0.43) | NR1H2MAPK1 | |
| SCHEMBL306475 | 0.76 | NR1H2 (0.31) | NR1H2 | |
| SCHEMBL4103214 | 0.76 | MAPK1 (0.32) | MAPK1 | |
| SCHEMBL14938602 | 0.75 | NR1H2 (0.33) | NR1H2 | |
| SCHEMBL7839758 | 0.75 | DPP4 (0.42) | NR1H2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2934533-A2 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2015-10-28 | — | — | EP | disclosed |
| EP-2790511-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2014-10-22 | — | — | EP | disclosed |
| WO-2014099633-A2 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2014-06-26 | — | — | WO | disclosed |
| EP-2744499-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2014-06-25 | — | — | EP | disclosed |
| WO-2013090271-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2013-06-20 | — | — | WO | disclosed |
| WO-2013028474-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2013-02-28 | — | — | WO | disclosed |