Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364324 | 0.87 | DPP4 (0.32) | DPP4OPRM1OPRD1HRH3 | |
| SCHEMBL7419979 | 0.86 | DPP4 (0.43) | DPP4OPRM1OPRD1HRH3MAPK1 | |
| SCHEMBL7419982 | 0.86 | DPP4 (0.43) | DPP4OPRM1OPRD1HRH3MAPK1 | |
| SCHEMBL12898939 | 0.83 | ALDH1A1 (0.38) | DPP4HRH3 | |
| SCHEMBL25684409 | 0.83 | MAPK1 (0.37) | HRH3MAPK1HPGDCHRM2CHRM1 | |
| SCHEMBL12034086 | 0.81 | L3MBTL1 (0.33) | — | |
| SCHEMBL12034082 | 0.81 | L3MBTL1 (0.33) | — | |
| SCHEMBL1518056 | 0.81 | L3MBTL1 (0.33) | — | |
| SCHEMBL7435914 | 0.81 | CA12 (0.32) | — | |
| SCHEMBL1517868 | 0.81 | L3MBTL1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663912-B1 | HETEROCYCLIC ETHER COMPOUNDS THAT ENHANCE COGNITIVE FUNCTION | ABBOTT LAB (US) | 2001-12-12 | — | — | EP | disclosed |