Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 5/20 | 0.34 |
| ▸ | FASN | P49327 | 4/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | PDE9A | O76083 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720295 | 0.81 | FASN (0.43) | METFASNGSK3BHSD17B1HSD17B2 | |
| SCHEMBL14720347 | 0.75 | FASN (0.44) | METFASNGSK3BTRPM8ACACA | |
| SCHEMBL14720097 | 0.73 | FASN (0.60) | METFASNGSK3BTRPM8KDM1A | |
| SCHEMBL18106919 | 0.68 | FASN (0.44) | METFASNGSK3BHSD17B1HSD17B2 | |
| SCHEMBL14720219 | 0.67 | FASN (0.45) | METFASNGSK3BHSD17B1HSD17B2 | |
| SCHEMBL14720559 | 0.67 | FASN (0.43) | METFASNGSK3BHSD17B1HSD17B2 | |
| SCHEMBL14720341 | 0.66 | FASN (0.61) | FASNGSK3BHSD17B1HSD17B2ACACA | |
| SCHEMBL14720427 | 0.66 | FASN (0.61) | FASNGSK3BHSD17B1HSD17B2TRPM8 | |
| SCHEMBL14720304 | 0.65 | FASN (0.35) | FASNKDM1A | |
| SCHEMBL14720232 | 0.65 | FASN (0.59) | FASNGSK3BTRPM8KDM1AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2744333-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-06-25 | — | — | EP | disclosed |
| WO-2013028447-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |