Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1622025 | 0.88 | JAK2 (0.60) | JAK2JAK1USP30SLC2A1LIMK2 | |
| SCHEMBL1623986 | 0.88 | JAK2 (0.60) | JAK2JAK1USP30SLC2A1LIMK2 | |
| SCHEMBL15462496 | 0.88 | JAK2 (0.60) | JAK2JAK1USP30SLC2A1LIMK2 | |
| SCHEMBL14720201 | 0.86 | HDAC1 (0.52) | PKMHDAC1HDAC6KMT2A | |
| SCHEMBL15626828 | 0.82 | JAK2 (0.54) | JAK2JAK1USP30SLC2A1LIMK2 | |
| SCHEMBL1624362 | 0.82 | JAK2 (0.55) | JAK2JAK1USP30GPR119KDM4E | |
| SCHEMBL1622751 | 0.82 | JAK2 (0.55) | JAK2JAK1USP30GPR119KDM4E | |
| SCHEMBL1624057 | 0.82 | JAK2 (0.55) | JAK2JAK1USP30GPR119KDM4E | |
| SCHEMBL15538837 | 0.79 | KDM4E (0.50) | JAK2JAK1LIMK2GPR119KDM4E | |
| SCHEMBL3082993 | 0.78 | KDM4E (0.53) | JAK2JAK1SLC2A1LIMK2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028445-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |