Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 11/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL14720273 | 0.95 | PIK3CD (0.45) | PIK3CBPIK3CDPIK3CAPIK3CGSMN1; SMN2 | |
| Acetic Acid SCHEMBL14720283 | 0.81 | CDC7 (0.38) | — | |
| SCHEMBL14720396 | 0.81 | PIK3CD (0.38) | PIK3CBPIK3CDPIK3CAPIK3CGSMN1; SMN2 | |
| SCHEMBL13516642 | 0.79 | MEN1 (0.43) | SMN1; SMN2MAPT | |
| SCHEMBL13516190 | 0.74 | KMT2A (0.42) | SMN1; SMN2MAPT | |
| SCHEMBL13516422 | 0.74 | ALDH1A1 (0.41) | SMN1; SMN2MAPT | |
| SCHEMBL13562088 | 0.74 | KMT2A (0.41) | SMN1; SMN2MAPT | |
| SCHEMBL14720301 | 0.71 | PIK3CB (0.53) | PIK3CBPIK3CDPIK3CAPIK3CGSMN1; SMN2 | |
| SCHEMBL13516125 | 0.70 | PTGDR2 (0.42) | SMN1; SMN2MAPT | |
| SCHEMBL14720221 | 0.70 | PIK3CB (0.58) | PIK3CBPIK3CDPIK3CAPIK3CGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028263-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |