Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721114 | 0.78 | SLC18A3 (0.53) | HDAC1KMT2AHRH3POLBMEN1 | |
| SCHEMBL14720459 | 0.77 | HDAC1 (0.46) | HDAC1HRH3POLBSMN1; SMN2 | |
| SCHEMBL14720750 | 0.75 | HRH3 (0.46) | HDAC1HRH3TSHRPOLB | |
| SCHEMBL14720929 | 0.75 | HRH3 (0.46) | HDAC1HRH3POLB | |
| SCHEMBL17455542 | 0.74 | HRH3 (0.50) | HDAC1KMT2AHRH3POLBMEN1 | |
| SCHEMBL16055301 | 0.74 | ACHE (0.52) | HDAC1KMT2AHRH3POLBMEN1 | |
| SCHEMBL4206550 | 0.74 | ACHE (0.58) | KMT2AHRH3POLBMEN1 | |
| SCHEMBL14720930 | 0.73 | HRH3 (0.43) | HDAC1HRH3POLB | |
| SCHEMBL14730983 | 0.73 | HRH3 (0.43) | HDAC1HRH3POLB | |
| SCHEMBL14730640 | 0.73 | HRH3 (0.43) | HDAC1HRH3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |