SCHEMBL14720787

SCHEMBL14720787

CCN1CCC(=Cc2ccc(C(O)C3CCCC3)cc2)CC1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 2/20 0.43
MCHR1 Q99705 2/20 0.43
HRH3 Q9Y5N1 2/20 0.43
HTR2A P28223 3/20 0.40
HTR2C P28335 2/20 0.40
HTR7 P34969 1/20 0.40
CARM1 Q86X55 1/20 0.40
PRMT6 Q96LA8 1/20 0.40
DHODH Q02127 1/20 0.39
KDM4E B2RXH2 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
TSHR P16473 1/20 0.39
ALDH1A1 P00352 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14720777 0.88 MCHR1 (0.44) SRD5A2MCHR1HRH3HTR2AHTR2C
SCHEMBL14720870 0.86 MCHR1 (0.52) SRD5A2MCHR1HRH3HTR2AHTR2C
SCHEMBL14720586 0.85 MCHR1 (0.42) SRD5A2MCHR1HRH3ALDH1A1
SCHEMBL14720584 0.82 SRD5A2 (0.47) SRD5A2MCHR1HRH3
SCHEMBL14720717 0.82 SRD5A2 (0.43) SRD5A2MCHR1HRH3HTR2AHTR2C
SCHEMBL14720591 0.81 SRD5A2 (0.44) SRD5A2MCHR1HRH3HTR2AHTR2C
SCHEMBL14720998 0.80 SRD5A2 (0.57) SRD5A2MCHR1HRH3DHODH
SCHEMBL14720425 0.77 DHODH (0.40) SRD5A2MCHR1HRH3DHODH
SCHEMBL14721037 0.76 SRD5A2 (0.47) SRD5A2MCHR1DHODHALDH1A1
SCHEMBL14721354 0.74 HRH3 (0.47) SRD5A2HRH3CARM1PRMT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO claimed
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO disclosed
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO disclosed