SCHEMBL14720591

SCHEMBL14720591

OC(c1ccc(C=C2CCN(C3CCC3)CC2)cc1)C1CCCC1

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 4/20 0.44
HRH3 Q9Y5N1 2/20 0.40
DHODH Q02127 1/20 0.37
SRD5A1 P18405 1/20 0.36
MCHR1 Q99705 1/20 0.35
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR7 P34969 1/20 0.33
CHRM2 P08172 1/20 0.32
CHRM1 P11229 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14720831 0.90 HRH3 (0.42) SRD5A2HRH3MCHR1
SCHEMBL14720522 0.84 HRH3 (0.39) SRD5A2HRH3MCHR1CHRM2CHRM1
SCHEMBL14721351 0.84 MCHR1 (0.40) SRD5A2HRH3SRD5A1MCHR1
SCHEMBL14721353 0.84 SRD5A2 (0.42) SRD5A2HRH3SRD5A1MCHR1
SCHEMBL14722438 0.83 HRH3 (0.39) SRD5A2HRH3MCHR1CHRM2CHRM1
SCHEMBL14720721 0.82 HRH3 (0.36) SRD5A2HRH3SRD5A1MCHR1
SCHEMBL14723242 0.81 SRD5A2 (0.47) SRD5A2HRH3SRD5A1CHRM1
SCHEMBL14731163 0.81 MCHR1 (0.38) SRD5A2HRH3SRD5A1MCHR1
SCHEMBL14720884 0.81 HRH3 (0.36) SRD5A2HRH3DHODHSRD5A1CHRM2
SCHEMBL14720787 0.81 SRD5A2 (0.43) SRD5A2HRH3DHODHMCHR1HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO claimed
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO disclosed
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO disclosed