Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721010 | 0.88 | SRD5A2 (0.39) | SRD5A2SRD5A1HRH3MCHR1ALDH1A1 | |
| SCHEMBL14720849 | 0.85 | SRD5A2 (0.38) | SRD5A2SRD5A1HRH3MCHR1ALDH1A1 | |
| SCHEMBL14723242 | 0.85 | SRD5A2 (0.47) | SRD5A2SRD5A1HRH3CHRM1GAA | |
| SCHEMBL14720522 | 0.83 | HRH3 (0.39) | SRD5A2HRH3MCHR1CHRM1 | |
| SCHEMBL14721067 | 0.82 | SRD5A2 (0.42) | SRD5A2SRD5A1HRH3ALDH1A1L3MBTL1 | |
| SCHEMBL14721400 | 0.82 | SRD5A2 (0.48) | SRD5A2SRD5A1HRH3MCHR1ALDH1A1 | |
| SCHEMBL14720815 | 0.82 | SRD5A2 (0.38) | SRD5A2SRD5A1HRH3MCHR1ALDH1A1 | |
| SCHEMBL14731084 | 0.82 | SRD5A2 (0.36) | SRD5A2SRD5A1HRH3ALDH1A1MEN1 | |
| SCHEMBL14722438 | 0.82 | HRH3 (0.39) | SRD5A2HRH3MCHR1CHRM1 | |
| SCHEMBL14720475 | 0.81 | SRD5A2 (0.39) | SRD5A2SRD5A1HRH3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |