Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14732935 | 0.88 | DGAT1 (0.38) | DGAT1NPC1P2RX7MAPT | |
| SCHEMBL16977981 | 0.84 | NPC1 (0.34) | DGAT1NPC1MAPT | |
| SCHEMBL34475404 | 0.83 | NPC1 (0.33) | DGAT1NPC1MAPT | |
| SCHEMBL16967499 | 0.82 | DGAT1 (0.36) | DGAT1NPC1P2RX7MAPTNR3C1 | |
| SCHEMBL30877406 | 0.80 | NPC1 (0.32) | NPC1MAPT | |
| SCHEMBL14722573 | 0.78 | MAPT (0.37) | DGAT1NPC1MAPT | |
| SCHEMBL30469343 | 0.78 | AAK1 (0.34) | P2RX7 | |
| SCHEMBL21788774 | 0.78 | MAPT (0.37) | DGAT1NPC1MAPTNR3C1 | |
| SCHEMBL14732936 | 0.77 | DGAT1 (0.43) | DGAT1P2RX7MAPTNR3C1 | |
| SCHEMBL29452528 | 0.76 | NPC1 (0.35) | NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
| EP-2748164-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | Merck Patent GmbH (DE) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013026516-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | CDK1, CDK2, CDK4 | DGAT1 4530/4885NPC1 3549/4885P2RX7 987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.