Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 14/20 | 0.40 |
| ▸ | IGF1R | P08069 | 7/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PAK3 | O75914 | 1/20 | 0.34 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL14723505 | 0.92 | MKNK1 (0.36) | ROCK2ROCK1MKNK1MKNK2NTRK1 | |
| SCHEMBL15059363 | 0.88 | MKNK1 (0.41) | ROCK2ROCK1MKNK1MKNK2NTRK1 | |
| SCHEMBL15209627 | 0.88 | PAK3 (0.43) | NTRK1IGF1RPAK1NTRK3NTRK2 | |
| SCHEMBL15208674 | 0.88 | ROCK2 (0.41) | ROCK2ROCK1MKNK1MKNK2NTRK1 | |
| SCHEMBL14723576 | 0.85 | NTRK1 (0.39) | ROCK2ROCK1MKNK1MKNK2NTRK1 | |
| SCHEMBL15208544 | 0.84 | MKNK1 (0.40) | ROCK2ROCK1MKNK1MKNK2NTRK1 | |
| SCHEMBL15209336 | 0.84 | NTRK1 (0.41) | ROCK2ROCK1MKNK1MKNK2NTRK1 | |
| SCHEMBL15209430 | 0.83 | NTRK1 (0.37) | NTRK1IGF1RNTRK3NTRK2CYP1A2 | |
| SCHEMBL15059155 | 0.83 | MKNK1 (0.53) | ROCK2ROCK1MKNK1MKNK2NTRK1 | |
| SCHEMBL15058505 | 0.82 | MKNK1 (0.46) | ROCK2ROCK1MKNK1MKNK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748159-A1 | SERINE/THREONINE PAK1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-02 | — | — | EP | disclosed |
| US-8637537-B2 | Serine/threonine kinase inhibitors | GENENTECH, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20130225620-A1 | SERINE/THREONINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2013-08-29 | — | — | US | disclosed |
| WO-2013026914-A1 | SERINE/THREONINE PAK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225620-A1 | SERINE/THREONINE KINASE INHIBITORS | PAK1, AKT1, RB1 | ROCK2 66/4885ROCK1 20/4885MKNK1 176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.