Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15960759 | 1.00 | CYP2C9 (0.52) | CYP2C9CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL2340681 | 0.94 | CYP2C9 (0.52) | CYP2C9CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL2335500 | 0.93 | CYP2C9 (0.54) | CYP2C9CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL2333455 | 0.93 | CYP2C9 (0.54) | CYP2C9CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL2338076 | 0.91 | CYP2C9 (0.51) | CYP2C9CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL2336737 | 0.90 | CYP2C9 (0.56) | CYP2C9CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL2337106 | 0.89 | CYP2C9 (0.52) | CYP2C9CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL2335941 | 0.88 | CYP2C9 (0.53) | CYP2C9CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL2339912 | 0.88 | CYP2C9 (0.53) | CYP2C9CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL2334232 | 0.87 | CYP2C9 (0.53) | CYP2C9CYP2C19ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748147-A1 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | St. Jude Children's Research Hospital (US) | 2014-07-02 | — | — | EP | claimed |
| WO-2013027196-A9 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4- TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2013-04-18 | — | — | WO | claimed |
| WO-2013027196-A1 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4- TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2013-02-28 | — | — | WO | claimed |
| EP-2748147-B1 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | ST JUDE CHILDREN'S RES HOSPITAL (US) | 2017-08-02 | — | — | EP | disclosed |
| US-9416124-B2 | Substituted 2-alkyl-1-OXO-N-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoquinoline-4-carboxamides for antimalarial therapies | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2016-08-16 | — | — | US | disclosed |
| US-20140235593-A1 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2014-08-21 | — | — | US | disclosed |
| CN-103930404-A | Substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-1, 2,3, 4-tetrahydroisoquinoline-4-amides for use in a method of treatment against malaria | ST JUDE CHILDRENS RES HOSPITAL | 2014-07-16 | — | — | CN | disclosed |
| EP-2748147-A1 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | St. Jude Children's Research Hospital (US) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013027196-A9 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4- TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2013-04-18 | — | — | WO | disclosed |
| WO-2013027196-A1 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4- TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235593-A1 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | QTRT1, GLS2, QTRT2 | CYP2C9 472/4885CYP2C19 450/4885ALDH1A1 2752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.