Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 15/20 | 0.43 |
| ▸ | UBA3 | Q8TBC4 | 15/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14723130 | 0.84 | NAE1 (0.45) | NAE1UBA3CRHR1 | |
| SCHEMBL783690 | 0.80 | NAE1 (0.59) | NAE1UBA3 | |
| SCHEMBL783623 | 0.80 | NAE1 (0.59) | NAE1UBA3 | |
| SCHEMBL12392783 | 0.80 | NAE1 (0.59) | NAE1UBA3 | |
| SCHEMBL5140410 | 0.77 | NAE1 (0.44) | NAE1UBA3CRHR1 | |
| SCHEMBL14723290 | 0.76 | NAE1 (0.46) | NAE1UBA3 | |
| SCHEMBL783906 | 0.76 | NAE1 (0.58) | NAE1UBA3MAPK1AURKARPS6KB1 | |
| SCHEMBL10005118 | 0.76 | NAE1 (0.48) | NAE1UBA3CRHR1AURKARPS6KB1 | |
| SCHEMBL17865997 | 0.76 | NAE1 (0.48) | NAE1UBA3CRHR1AURKARPS6KB1 | |
| SCHEMBL12453638 | 0.75 | NAE1 (0.51) | NAE1UBA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2748168-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013028832-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-28 | — | — | WO | disclosed |