Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 8/20 | 0.66 |
| ▸ | MAPK10 | P53779 | 10/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722176 | 0.80 | DGAT1 (0.41) | PTK2 | |
| SCHEMBL14722939 | 0.80 | PTK2 (1.00) | PTK2MAPK10MAPK9WDR5FGFR1 | |
| SCHEMBL14733063 | 0.73 | PTK2 (1.00) | PTK2MAPK10MAPK9FGFR1 | |
| SCHEMBL17289994 | 0.71 | CNR2 (0.43) | — | |
| SCHEMBL16967473 | 0.68 | PTK2 (0.80) | PTK2MAPK10MAPK9MAPK8FGFR1 | |
| SCHEMBL14732949 | 0.67 | PTK2 (0.78) | PTK2MAPK10MAPK9MAPK8FGFR1 | |
| SCHEMBL1231775 | 0.67 | MAPK10 (1.00) | PTK2MAPK10MAPK9 | |
| SCHEMBL1231705 | 0.66 | MAPK10 (0.85) | PTK2MAPK10MAPK9 | |
| SCHEMBL31271222 | 0.66 | JAK2 (0.42) | — | |
| SCHEMBL1232329 | 0.65 | MAPK10 (0.85) | PTK2MAPK10MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-9249140-B2 | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-08-06 | — | — | US | disclosed |
| EP-2748164-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | Merck Patent GmbH (DE) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013026516-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013026516-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218155-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS | CDK1, CDK2, CDK4 | PTK2 1291/4885MAPK10 729/4885MAPK9 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.