SCHEMBL14723518

SCHEMBL14723518

CN1Cc2cc(NS(=O)(=O)c3ccccc3Cl)ccc2NC1=O

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 20/20 0.78
CREBBP Q92793 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14721529 0.88 BRD4 (0.70) BRD4CREBBP
SCHEMBL14722103 0.87 BRD4 (0.69) BRD4CREBBP
SCHEMBL14722139 0.87 BRD4 (1.00) BRD4CREBBP
SCHEMBL14722430 0.86 BRD4 (1.00) BRD4CREBBP
SCHEMBL14722824 0.86 BRD4 (1.00) BRD4CREBBP
SCHEMBL29430449 0.84 BRD4 (1.00) BRD4CREBBP
SCHEMBL14721611 0.84 BRD4 (1.00) BRD4CREBBP
SCHEMBL16771914 0.84 BRD4 (0.74) BRD4CREBBP
SCHEMBL16760624 0.84 BRD4 (0.70) BRD4CREBBP
SCHEMBL16771456 0.83 BRD4 (0.72) BRD4CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013027168-A1 NOVEL HETEROCYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS PFIZER INC. (US) 2013-02-28 WO disclosed