Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16436961 | 0.89 | KMT2A (0.55) | HDAC1HDAC6HDAC3HDAC2HDAC11 | |
| SCHEMBL16472105 | 0.88 | KMT2A (0.51) | HDAC1HDAC6HDAC3HDAC2HDAC11 | |
| SCHEMBL20660653 | 0.86 | OPRK1 (0.59) | KMT2AMEN1OPRK1 | |
| SCHEMBL20660561 | 0.86 | OPRK1 (0.59) | KMT2AMEN1OPRK1 | |
| SCHEMBL20660719 | 0.86 | OPRK1 (0.59) | KMT2AMEN1OPRK1 | |
| SCHEMBL28398818 | 0.86 | OPRK1 (0.59) | KMT2AMEN1OPRK1 | |
| SCHEMBL10620286 | 0.86 | OPRK1 (0.59) | KMT2AMEN1OPRK1 | |
| SCHEMBL29122639 | 0.86 | OPRK1 (0.59) | KMT2AMEN1OPRK1 | |
| SCHEMBL11284305 | 0.84 | OPRK1 (0.61) | KMT2AMEN1OPRK1L3MBTL1 | |
| SCHEMBL14723640 | 0.83 | HDAC1 (0.57) | HDAC1HDAC6HDAC3HDAC2HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9199923-B2 | Histone deacetylase inhibitors | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-12-01 | — | — | US | disclosed |
| US-20150038581-A1 | HISTONE DEACETYLASE INHIBITORS | Harvard University & Medical School | 2015-02-05 | — | — | US | disclosed |
| EP-2010168-B1 | HISTONE DEACETYLASE INHIBITORS | HARVARD COLLEGE (US) | 2014-04-16 | — | — | EP | disclosed |
| US-8383855-B2 | Histone deacetylase inhibitors | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383855-B2 | Histone deacetylase inhibitors | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038581-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC7 | HDAC1 1/4885HDAC6 16/4885HDAC3 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.