Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 11/20 | 0.33 |
| ▸ | AURKA | O14965 | 10/20 | 0.33 |
| ▸ | AXL | P30530 | 3/20 | 0.33 |
| ▸ | PLK4 | O00444 | 2/20 | 0.33 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | BCR | P11274 | 2/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | STK25 | O00506 | 1/20 | 0.33 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | MUSK | O15146 | 1/20 | 0.33 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1148246 | 0.94 | AURKB (0.33) | AURKBAURKAAXLPLK4AURKC | |
| SCHEMBL1147573 | 0.83 | AURKB (0.41) | AURKBAURKAAXLPLK4AURKC | |
| SCHEMBL13219751 | 0.82 | AURKB (0.50) | AURKBAURKAAXLPLK4AURKC | |
| SCHEMBL1147563 | 0.81 | AURKB (0.49) | AURKBAURKAAXLPLK4AURKC | |
| SCHEMBL13004281 | 0.78 | AURKA (0.39) | AURKBAURKAAXLPLK4AURKC | |
| SCHEMBL1147568 | 0.74 | PTGES (0.35) | CHEK1 | |
| SCHEMBL14021480 | 0.73 | JAK1 (0.33) | AURKBAURKAAXLPLK4AURKC | |
| SCHEMBL13199435 | 0.71 | AURKB (0.43) | AURKBAURKAAXLPLK4AURKC | |
| SCHEMBL16156485 | 0.70 | AURKB (0.41) | AURKBAURKAAXLPLK4AURKC | |
| SCHEMBL1148025 | 0.69 | AURKB (0.43) | AURKBAURKAAXLPLK4AURKC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383633-B2 | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-26 | — | — | US | disclosed |