Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 6/20 | 0.37 |
| ▸ | ITGAL | P20701 | 4/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1952237 | 0.92 | GPR183 (0.46) | GPR183NFKB1MAPTL3MBTL1MAOB | |
| SCHEMBL1952234 | 0.92 | GPR183 (0.46) | GPR183NFKB1MAPTL3MBTL1MAOB | |
| SCHEMBL1953413 | 0.89 | GPR183 (0.48) | GPR183NFKB1MAPTL3MBTL1MAOB | |
| SCHEMBL1953415 | 0.89 | GPR183 (0.48) | GPR183NFKB1MAPTL3MBTL1MAOB | |
| SCHEMBL1950810 | 0.81 | GPR183 (0.50) | GPR183NFKB1MAPTL3MBTL1MAOB | |
| SCHEMBL1950814 | 0.81 | GPR183 (0.50) | GPR183NFKB1MAPTL3MBTL1MAOB | |
| SCHEMBL14723859 | 0.81 | CNR1 (0.48) | MAPTLMNAATMSMN1; SMN2NPSR1 | |
| SCHEMBL14723874 | 0.80 | OPRD1 (0.44) | MAPTLMNAGAAATMSMN1; SMN2 | |
| SCHEMBL15061818 | 0.76 | GPR183 (0.44) | GPR183NFKB1MAPTL3MBTL1MAOB | |
| SCHEMBL12569927 | 0.75 | GPR183 (0.44) | GPR183NFKB1MAPTMAOBITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383629-B2 | Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 | VITAE PHARMACEUTICALS, INC. (US) | 2013-02-26 | — | — | US | disclosed |