Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 5/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1950810 | 0.86 | GPR183 (0.50) | GPR183MAPTL3MBTL1KDM4ENPC1 | |
| SCHEMBL1950814 | 0.86 | GPR183 (0.50) | GPR183MAPTL3MBTL1KDM4ENPC1 | |
| SCHEMBL1953413 | 0.74 | GPR183 (0.48) | GPR183MAPTL3MBTL1RAB9AKMT2A | |
| SCHEMBL1953415 | 0.74 | GPR183 (0.48) | GPR183MAPTL3MBTL1RAB9AKMT2A | |
| SCHEMBL12548597 | 0.74 | PDE7A (0.47) | GPR183APPHPGDMAPTL3MBTL1 | |
| SCHEMBL12548905 | 0.73 | GPR183 (0.44) | GPR183APPHPGDMAPTL3MBTL1 | |
| SCHEMBL14723844 | 0.72 | GPR183 (0.47) | GPR183MAPTL3MBTL1 | |
| SCHEMBL1949275 | 0.71 | GPR183 (0.51) | GPR183MAPTL3MBTL1KDM4ENPC1 | |
| SCHEMBL1949277 | 0.71 | GPR183 (0.51) | GPR183MAPTL3MBTL1KDM4ENPC1 | |
| SCHEMBL11477379 | 0.70 | GPR183 (0.56) | GPR183APPHPGDMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383629-B2 | Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 | VITAE PHARMACEUTICALS, INC. (US) | 2013-02-26 | — | — | US | disclosed |