Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 6/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.37 |
| ▸ | ITGAL | P20701 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1953162 | 0.89 | GPR183 (0.46) | GPR183NFKB1MAOBP4HBABCG2 | |
| SCHEMBL1953164 | 0.89 | GPR183 (0.46) | GPR183NFKB1MAOBP4HBABCG2 | |
| SCHEMBL12569866 | 0.80 | GPR183 (0.47) | GPR183NFKB1MAOBP4HBABCG2 | |
| SCHEMBL1953441 | 0.77 | GPR183 (0.47) | GPR183NFKB1MAOBP4HBABCG2 | |
| SCHEMBL1953443 | 0.77 | GPR183 (0.47) | GPR183NFKB1MAOBP4HBABCG2 | |
| SCHEMBL14723842 | 0.76 | GPR183 (0.48) | GPR183NFKB1MAOBP4HBABCG2 | |
| SCHEMBL12569944 | 0.76 | GPR183 (0.48) | GPR183NFKB1MAOBHRH3 | |
| SCHEMBL28905813 | 0.76 | NFKB1 (0.71) | GPR183NFKB1MAOBP4HBABCG2 | |
| Hydrochloric Acid SCHEMBL1951182 | 0.76 | GPR183 (0.46) | GPR183NFKB1MAOBP4HBABCG2 | |
| SCHEMBL14723839 | 0.74 | GPR183 (0.46) | GPR183NFKB1MAOBP4HBABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383629-B2 | Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 | VITAE PHARMACEUTICALS, INC. (US) | 2013-02-26 | — | — | US | disclosed |