Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.58 |
| ▸ | REN | P00797 | 1/20 | 0.58 |
| ▸ | CTSD | P07339 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14878030 | 1.00 | BACE1 (0.58) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL3365249 | 1.00 | BACE1 (0.58) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL5505443 | 0.92 | BACE1 (0.57) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL13114565 | 0.91 | BACE1 (0.62) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL3364771 | 0.91 | BACE1 (0.62) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL1414274 | 0.91 | BACE1 (0.51) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL1414460 | 0.91 | BACE1 (0.51) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL14723921 | 0.86 | BACE1 (0.77) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL3365938 | 0.86 | BACE1 (0.77) | BACE1RENCTSDKCNH2BACE2 | |
| SCHEMBL1414117 | 0.85 | BACE1 (0.49) | BACE1RENCTSDKCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436006-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-05-07 | — | — | US | disclosed |
| US-8426429-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-04-23 | — | — | US | disclosed |
| US-8383637-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-02-26 | — | — | US | disclosed |