SCHEMBL14724401

SCHEMBL14724401

Cc1c(F)cc(F)c(F)c1CO

nearest known ligand 0.32

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
CA1 P00915 2/20 0.32
CA2 P00918 2/20 0.32
CA4 P22748 2/20 0.32
GABRA1 P14867 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
DHODH Q02127 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GLA P06280 1/20 0.31
GAA P10253 1/20 0.31
KLK7 P49862 1/20 0.31
ATM Q13315 1/20 0.31
GCGR P47871 1/20 0.30
P2RX7 Q99572 1/20 0.30
CES2 O00748 1/20 0.30
CES1 P23141 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19688000 0.88 HDAC1 (0.35) HDAC1HDAC6GABRA1GABRG2GABRB3
SCHEMBL358960 0.83 CA1 (0.39) CA1CA2CA4GABRA1GABRG2
SCHEMBL15214999 0.79
SCHEMBL11054959 0.77 SHBG (0.41) KDM4EALDH1A1GCGR
SCHEMBL24982666 0.74 DPP4 (0.33)
SCHEMBL24982779 0.74 DPP4 (0.32)
SCHEMBL29756095 0.73 CA1 (0.36) CA1CA2CA4CES2CES1
SCHEMBL364805 0.73 CA1 (0.36) CA1CA2CA4CES2CES1
SCHEMBL19478295 0.73 CA1 (0.32) CA1CA2CA4CES2CES1
SCHEMBL19478153 0.73 DRD4 (0.34) CA1CA2CA4CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109195944-B Ester compound and use thereof 大日本除虫菊株式会社 2022-06-14 CN disclosed
CN-109195944-A ester compound and use thereof 大日本除虫菊株式会社 2019-01-11 CN disclosed
EP-2562165-A1 5-FLUORO PYRIMIDINE DERIVATIVES AS FUNGICIDES Dow AgroSciences LLC (US) 2013-02-27 EP disclosed
EP-2562163-A1 5-FLUORO PYRIMIDINE DERIVATIVES AS FUNGICIDES Dow AgroSciences LLC (US) 2013-02-27 EP disclosed
EP-2562166-A1 5-FLUORO PYRIMIDINE DERIVATIVES AS FUNGICIDES Dow AgroSciences LLC (US) 2013-02-27 EP disclosed